ESPE Yearbook of Paediatric Endocrinology

To read the full abstract: Endocrinology 2019;160:2165–2179This paper characterize viral insulin/IGF-1–like peptides (VILPs), which the authors identified in four members of the Iridoviridae family - viruses with double-stranded DNA genomes, which are found in amphibians, fish, and invertebrates. VILPs can bind to human insulin and IGF-1 receptors and stimulate classic post-receptor signaling pathways. They can stimulate glucose uptake...

To read the full abstract: Science 2018;361:76–81.The tuberal nucleus (TN) is a hypothalamic region which is well described in humans but remains poorly defined in rodents. In this paper, the authors demonstrated by specific and sophisticated techniques the role of somatostatin expressing TN (TNSST) neurons in the control of food intake in mice. Interestingly, their resul...